Lecture: Enzymes at Work
This month, we have the honor of presenting Guillermo Montoya and Jakob Nilsson from the Novo Nordisk Foundation Center for Protein Research who will present their findings and provide insight in to different approaches to determining basic principles in proteins.
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Prof. Jakob Nilsson: Finding the right phosphate – specificity determinants of protein phosphatases
Protein phosphatases are enzymes that remove phosphorylations from proteins to regulate signaling in eukaryotes. Despite their fundamental role in controlling all aspects of cellular function across eukaryotes we have a limited understanding of how these enzymes achieve specificity. Our work focuses on understanding the basic principles of substrate selection for protein phosphatases and how this controls fundamental biological processes.
Prof. Guillermo Montoya: How cryoEM transformed structural biology in a movie studio by visualising dynamic states of macromolecular complexes
Among other things, Guillermo will give an account of how cryo-Electron Microscopy, CryoEM, is used for structural and cell biology projects. The resolution revolution in CryoEM has provided researchers with new opportunities to study the structure of proteins in unprecedented detail. The development of this technology was awarded the Nobel Prize for facilitating the analysis of previously very difficult protein structures. Few examples will be shown on recent structural work of his group in CRSPR-Cas and protein-signalling complexes
Note that this lecture will only be accessible online. Register to receive a link on the day of the event.
Facts
Programme
Finding the right phosphate – specificity determinants of protein phosphatases
How Cryo-EM transformed structural biology in a movie studio by visualising dynamic states of macromolecular complexes
