Event by Novo Nordisk Foundation Science Cluster

    Lecture: Proteomics technologies shed light on cellular and disease mechanisms

    The Copenhagen Bioscience Lectures are a series of open lectures for all researchers and other interested in and around the Copenhagen area. Every 4 weeks, on a Thursday evening, you are invited for lectures on themes with a general interest for the Novo Nordisk Foundation Research Centers and bioscience researchers in general. Often there will be a cross-disciplinary focus. We are happy to announce Matthias Mann with a talk about how “Proteomics technologies shed light on cellular and disease mechanisms”. His colleage Alberto Santos Delgado will present “A clinical knowledge graph for Big Data: from data and networks to understanding”. Mass spectrometry (MS)-based proteomics aims to identify and quantify all the proteins and their modification state in a biological system. The current state of this technology will briefly be summarized, followed by examples of its use in diverse biological and medical areas. Matthias Mann’s group has used cancer proteomics to discover a biomarker of ovarian cancer called CT45. Women, who express this protein have almost doubled survival time and we have employed multiple dimensions of proteomics to define the mechanism by which this happens (Coscia, et al. Cell 2018). Furthermore, by ‘phospho proteomics’ they can determine the activation state of thousands of proteins. They have used this technology to unravel the elusive substrate of the LRRK2 kinase, which when mutated causes Parkinson’s disease with very high penetrance (Steger et al, eLife 2016, 2017) and shown proof of principle that the harmful effects of opioid signaling can be suppressed in a targeted manner (Jeff Liu, et al. Science 2018). Finally, Matthias Mann will discuss the current state of Plasma Proteomics Profiling, a new technology to determine the health or disease state from the proteins in a finger prick of blood plasma.

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    08 November 2018


    Matthias Mann Professor at the NNF Center for Protein Research
    Alberto Santos Delgado Postdoc at the NNF Center for Protein Research


    Registration is completely free of charge, but mandatory. Deadline for registration is November 6, 2018.


    3:45 pm Welcome and registration (coffee/tea, water available)
    4:00 pm Start of the lecture
    5:30 pm Networking with a drink and a snack
    6:30 pm Thank you for a splendid end of day!
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    I would like to know about upcoming Copenhagen Bioscience Lectures – where can I find information?

    You are very welcome to join the ‘Novo Nordisk Foundation Research Centers’ Linkedin group. There you will find information about upcoming lectures, and much more. Also, you may want to sign up for the weekly announcement with events and deadlines, sent out by the group manager.

    What are my transport/parking options getting to the event?

    The organiser offers to pay for a taxi on the following conditions: it has to be transport from either Panum/Mærsk Tower or DTU building 220, if you are at least 3 people in a taxi. This is how it works: you arrange yourself for a taxi from Blegdamsvej or from Kemitorvet, find at least 2 other people to take the taxi with, and at arrival at Tuborg Havnevej 19 you ask Sophie to come and pay for the taxi (they’ll check departure address and number of persons in the taxi), as well as to order your taxi back.

    If you are by car, you can park for free in front or at the side of Tuborg Havnevej 19. If that is full, there is 3 hours free parking in the parking to the Waterfront shopping mall at the end of the road.

    Public transport by train to Hellerup station, and/or bus (1A, 21, 166), nearest by bus stop is Tuborg Boulevard.

    Where can I contact the organizer with any questions?

    Contact Sophie Labrosse at sfeb@novo.dk

    How do I cancel my participation?

    Please help us respecting our speakers, as well as keeping track of the numbers and optimize lecture and catering to the audience by cancelling as soon as you know that you exceptionally will not be able to make it. You can either cancel through Eventbrite or send an email to Sophie Labrosse (sfeb@novo.dk).

    Can I update my registration information?

    Yes, just log in to Eventbrite. Please use this option also in the unlikely event that you need to cancel your registration.

    Do I have to bring my printed ticket to the event?

    No, you do not have to bring your ticket, but registration is mandatory for participation.