Event by Novo Nordisk Foundation Science Cluster

    Protein Signaling - from pathways to networks

    Most therapeutic drugs are directed against proteins or are proteins themselves, and protein-related technologies promise to revolutionize our understanding of the complex wiring of biological systems. Protein signaling is the eukaryotic cell’s most important regulatory mechanism to appropriately respond to internal and external cues. This intracellular signaling response is mediated by numerous site-specific post-translational modifications (PTMs) of proteins, including phosphorylation, ubiquitylation, and acetylation. Such regulatory PTMs are involved in virtually all signaling pathways that orchestrate fundamental cellular processes including cell cycle progression, apoptosis, the DNA damage response, autophagy, and metabolism. This meeting will bring together world leading researchers in the area of protein signaling. Focus will be on the protein-driven mechanisms that have fundamental roles in many pathological conditions, including cancer, hematopoietic and immune deficiencies, metabolic disorders, and aging. The meeting will also have a strong emphasis on emerging protein technologies that will allow researchers to gain a better understanding of how protein pathways are integrated with signaling networks, and how these coordinate complex biological processes.

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    02-06 October 2016


    Albert Heck Biomolecular Mass Spectrometry and Proteomics, Utrecht, The Netherlands
    Anne-Claude Gavin European Molecular Biology Laboratory (EMBL) Heidelberg, Germany
    Brenda Schulman St. Jude Children's Research Hospital, Memphis, United States
    Daniel Durocher The Lunenfeld-Tanenbaum Research Institute, Toronto, Canada
    Gianni Cesareni University of Rome Tor Vergata, Rome, Italy
    Giulio Superti-Furga CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
    Ileana Cristea Princeton University, Department of Molecular Biology, United States
    Ivan Dikic Institut für Biochemie II, Frankfurt am Mein, Germany
    James Ferrell Dept. of Chemical and Systems Biology, Stanford University of Medicine, United States
    Jason Chin MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Jiri Lukas Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark
    Julio Saez-Rodriguez EMBL-EBI, Cambridgeshire, United Kingdom
    Marc Kirschner Department of Systems Biology, Harvard Medical School, Boston, United States
    Matthias Mann Max-Planck-Institut für Biochemie, Martinsried, Germany
    Nevan Krogan Department of Cellular and Molecular Pharmacology, UCSF, United States
    Oscar Fernandez-Capetillo Howard Hughes Medical Institute, Chevy Chase, United States
    Ray Deshaies Howard Hughes Medical Institute, California Institute of Technology, Pasadena, United States
    Ronald Hay University of Dundee, Dundee, Scotland, United Kingdom
    Steve Jackson University of Cambridge, Cancer Research UK Gurdon Institute, Cambridge, United Kingdom
    Søren Brunak The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark
    Titia Sixma Division of Biochemistry, Netherlands Cancer Institute, Amsterdam, The Netherlands
    Wade Harper Department of Cell Biology, Harvard Medical School, Boston, United States

    Conference topics

    Conference topics

    DNA damage signaling
    Cell cycle
    Disease Pathways
    Signaling systems network
    Emerging technologies
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