Conference: PTMS in Cell Signaling

Post-translational modifications (PTMs) in cell signaling have evolved as the eukaryotic cell’s most important regulatory mechanism to regulate intracellular protein networks in response to external or internal cues. Site-specific modification of proteins by PTMs such as phosphorylation, ubiquitylation, and acetylation are involved in virtually all signaling pathways that orchestrate fundamental cellular processes including cell cycle progression, apoptosis, the DNA damage response, autophagy, and metabolism. Deregulation of proteins involved in these important cellular responses can often lead to disease, and the enzymes catalyzing addition or removal of PTMs have therefore emerged as promin ttent therapeutic targets. The meeting will focus on the cellular regulation of these fundamental processes by bringing together world leading researchers in the area of PTM functions in different cell signaling networks.